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The first election for Virginia's 5th congressional district took place on February 2, 1789, for a two-year term to commence on March 4 of that year. In a race that turned on the candidates' positions on the need for amendments (the Bill of Rights) to the recently ratified U.S. Constitution, James Madison defeated James Monroe for a place in the House of Representatives of the First Congress. It is the only congressional election in U.S. history in which two future presidents opposed each other. The race came about when former governor Patrick Henry and other Anti-Federalists in the Virginia General Assembly, who had opposed the state's ratification of the Constitution, sought to defeat Madison, who had been a strong advocate for ratification, and who wanted to become a member of the new House of Representatives; they had already defeated him in the legislative election to choose Virginia's first U.S. senators. They put forward Monroe, a young but experienced politician who was a war hero wounded at the 1776 Battle of Trenton, as a candidate for the seat. Monroe did not seek the contest, but once drafted campaigned vigorously. Despite bitterly cold weather, the two candidates debated outdoors; traveling after one such meeting, Madison suffered frostbite on his face. Although Madison had earlier stated that amendments to the Constitution were not necessary, during the campaign he took the position that they were, but should be proposed by Congress, rather than by an Article V Convention that Anti-Federalists such as Monroe and Henry supported. Madison won the election comfortably, to the satisfaction of his supporters such as President-elect George Washington. The race did not affect Madison's friendship with Monroe, who was elected to the Senate in 1790, and who would serve as Madison's Secretary of State and succeed him as president in 1817.

On June 19, 1838, the Maryland Province of the Society of Jesus agreed to sell 272 slaves to two Louisiana planters, Henry Johnson and Jesse Batey, for $115,000 (equivalent to approximately $3.25 million in 2023). This sale was the culmination of a contentious and long-running debate among the Maryland Jesuits over whether to keep, sell, or free their slaves, and whether to focus on their rural estates or on their growing urban missions, including their schools. In 1836, the Jesuit superior general, Jan Roothaan, authorized the Maryland provincial superior to carry out the sale on three conditions: the slaves must be permitted to practice their Catholic faith, their families must not be separated, and the proceeds of the sale must be used only to support Jesuits in training. It soon became clear that Roothaan's conditions had not been fully met. The Jesuits ultimately received payment many years late and never received the full $115,000. Only 206 of the 272 slaves were actually delivered because the Jesuits permitted the elderly and those with spouses who were living nearby and not owned by Jesuits to remain in Maryland. The sale prompted immediate outcry from fellow Jesuits. Some wrote emotional letters to Roothaan denouncing its immorality. Eventually, Roothaan removed Thomas Mulledy as provincial superior for disobeying orders and promoting scandal, exiling him to Nice for several years. Despite coverage of the Maryland Jesuits' slave ownership and the 1838 sale in academic literature, news of these facts came as a surprise to the public in 2015, prompting a study of Georgetown University's and the Jesuits' historical relationship with slavery. Georgetown and the College of the Holy Cross renamed buildings, Georgetown granted legacy admissions preference to the slaves' descendants, and the Jesuit Conference of Canada and the United States pledged to raise $100 million for them.

The 4th Missouri Infantry Regiment was formed on April 28, 1862, and served in the Confederate States Army during the American Civil War. The infantry regiment did not see action at the Battle of Farmington on May 9, and the Battle of Iuka on September 19 despite being part of the Confederate force present at those battles. As part of Brigadier General Martin E. Green's brigade, the regiment participated in three charges against Union lines on October 3, 1862, during the Second Battle of Corinth. The following day, the regiment, along with the rest of Green's brigade, attacked the new Union lines. Despite initial success, the attack was repulsed by a Union counterattack. The regiment ceased to exist as a separate unit when it was combined with the 1st Missouri Infantry Regiment on November 7, 1862, to form the 1st and 4th Missouri Infantry Regiment (Consolidated). The combined unit served in the Vicksburg campaign in 1863, before surrendering at the end of the siege of Vicksburg. After undergoing a prisoner exchange, the men rejoined the Confederate Army and served in the Atlanta Campaign and the Battle of Franklin in 1864, still as part of the 1st and 4th Missouri Infantry Regiment (Consolidated). On May 9, 1865, near the end of the war, the consolidated regiment surrendered during the Battle of Fort Blakeley, ending the unit's existence. The 4th Missouri Infantry's battle flag is displayed at the American Civil War Museum.

The 4th Pennsylvania Infantry Regiment, officially known as the 4th Regiment, Pennsylvania Volunteer Infantry, was an infantry regiment of the Union Army in the American Civil War. Formed mostly from a militia unit in Norristown in southeastern Pennsylvania, the regiment enlisted at the beginning of the American Civil War in April 1861 for a three-month period of service under the command of Colonel John F. Hartranft. Logistical difficulties bedeviled the regiment, which served as part of the garrison of Washington, D.C., until late June, when it was sent into Northern Virginia to join in the army of Brigadier General Irvin McDowell. The regiment suffered its only combat casualties in a picket action on June 30 and was sent back to be mustered out on the eve of the First Battle of Bull Run owing to disagreement among the men over remaining with the army after the expiration of their term of service. Its men were denounced as cowards for being members of the only regiment to refuse to fight at the July 21 battle. Hartranft and a company commander remained with the army and later received the Medal of Honor for their actions at Bull Run. Many men of the regiment went on to serve in new Pennsylvania regiments, forming the bulk of the 51st Pennsylvania Infantry, which fought for the rest of the war.

The 6th Regiment Massachusetts Volunteer Militia was a peacetime infantry regiment that was activated for federal service in the Union army for three separate terms during the American Civil War (1861-1865). The regiment gained notoriety as the first unit in the Union Army to suffer fatal casualties in action during the Civil War in the Baltimore Riot and the first militia unit to arrive in Washington D.C., in response to President Abraham Lincoln's initial call for 75,000 troops. Private Luther C. Ladd of the 6th Massachusetts is often referred to as the first Union soldier killed in action during the war. In the years immediately preceding the war and during its first enlistment, the regiment consisted primarily of companies from Middlesex County. During its first term of service, four out of ten companies of the regiment were from Lowell, Massachusetts. Colonel Edward F. Jones commanded the regiment during its first term. He later commanded the 26th Massachusetts and was awarded the honorary grade of brevet brigadier general. During its second and third terms of service, the unit was commanded by Colonel Albert S. Follansbee. The regiment first enlisted for a "90-day" term of service which lasted from April 16 to August 2, 1861. Following their engagement in the Baltimore Riot, the 6th Massachusetts proceeded to Washington and then returned to Baltimore to guard locations within the city as well as the Baltimore and Ohio Railroad station at Elkridge, Maryland. Their second term of service lasted nine months from August 1862 to June 1863. During this time the 6th Massachusetts was attached to the VII Corps and participated in several expeditions and actions in the vicinity of Suffolk, Virginia, most notably the siege of Suffolk and the Battle of Carrsville in April and May 1863. Private Joseph S.G. Sweatt's bravery at Carrsville earned him the Medal of Honor. The 6th Massachusetts served a third term in response to the call for troops to defend fortifications around Washington. During this term, which lasted 100 days from July to October 1864, the 6th Massachusetts garrisoned Fort C. F. Smith in Arlington, Virginia and guarded Confederate prisoners of war at Fort Delaware near the mouth of the Delaware River.

The 8th Missouri Infantry Regiment was an infantry regiment of the Confederate States Army during the American Civil War. From May 1861, the war began affecting events in the state of Missouri. In 1862, Confederate recruiting activities took place in Missouri, and a cavalry regiment was formed in Oregon County, the nucleus being former members of the Missouri State Guard. On September 2, the unit entered Confederate service, but it was reclassified as infantry ten days later. After many of the men transferred to other units, the regiment was reclassified as a battalion on October 19 and named the 7th Missouri Infantry Battalion, also known as Mitchell's Missouri Infantry. It participated in a Confederate offensive at the Battle of Prairie Grove on December 7. During the battle, the unit made several charges against the Union lines but was repeatedly repulsed by artillery fire. The regiment spent most of early 1863 encamped near Little Rock and Pine Bluff in Arkansas. On July 23, 1863, the unit was officially named the 8th Missouri Infantry Regiment. Later that year, it was part of the abortive Confederate defense of Little Rock before retiring to Camp Bragg near Camden. In March 1864, the regiment was sent south into Louisiana to help defend against the Red River campaign. It was part of a failed attack at the Battle of Pleasant Hill on April 9. After the Union troops involved in the Red River campaign retreated, the 8th Missouri Infantry was sent back to Arkansas, where it pursued the retreating Union soldiers led by Major General Frederick Steele. The regiment took part in a failed attack against Steele on April 30 at the Battle of Jenkins' Ferry. For the remainder of 1864 and the first half of 1865, the unit was stationed at several points in Louisiana and Arkansas. The Confederate Trans-Mississippi Department surrendered on June 2, 1865, and the men of the 8th Missouri Infantry Regiment were paroled on June 7, ending the regiment's military service.